Chapter Outline

20.1 Hans Krebs and the Discovery of the TCA Cycle

20.2 The TCA Cycle—A Brief Summary
20.3 The Bridging Step: Oxidative Decarboxylation of Pyruvate

20.4 Entry into the Cycle: The Citrate Synthase Reaction

20.5 The Isomerization of Citrate by Aconitase

20.6 Isocitrate Dehydrogenase—The First Oxidation in the Cycle

20.8 Succinyl-CoA Synthetase—A Substrate-Level Phosphorylation
20.9 Succinate Dehydrogenase—An Oxidation Involving FAD

20.10 Fumarase Catalyzes Trans-Hydration of Fumarate

20.11 Malate Dehydrogenase—Completing the Cycle

20.12 A Summary of the Cycle

20.14 The Anaplerotic, or “Filling Up,” Reactions

20.16 The Glyoxylate Cycle of Plants and Bacteria
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